Microenvironnement et cancers hématologiques

Brigitte Sola

PhD
Senior scientist CNRS

+ 33 2 31 56 82 10

Role of FUS/cyclin D1 dimers for double-stranded DNA breaks repair (in collaboration with Catherine Guette, INSERM UMR892, CRCNA, Angers)
Functional effects of XPO1 mutations (in collaboration with Luca Grumolato, UNIROUEN, INSERM U982, IRIB, Rouen and Fabrice Jardin , INSERM U1245, centre Henri Becquerel, Rouen)
Control of the glucidic metabolism by cyclin D1 in multiple myeloma cells (in collaboration with Olivier Hérault, LNox, CNRS UMR7292, University François Rabelais, Tours)

Body S, Esteve-Arenys A, Miloudi H, Recasens-Zorzo C, Tchakarska G, Moros A, Bustany S, Vidal-Crespo A, Rodriguez V, Lavigne R, Com E, Casanova I, Mangues R, Weigert O, Sanjuan A, Menéndez P, Marcq B, Piquenot JM, Pérez-Galán P, Jardin F, Roué G, Sola B. 2017. Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells. Sci Rep 2017; 7: 13946. PIMD: 29066743
Bustany S, Bourgeais J, Tchakarska G, Body S, Hérault O, Gouilleux F, Sola B. Cyclin D1 unbalances the redox status controlling cell adhesion, migration, and drug resistance in myeloma cells. Oncotarget 2015; 7: 45214-45224. PMID: 27286258
[Moros A, Bustany S], Cahu J, Saborit-Villaroya I, Martinez A, Colomer D, [Sola B, Roué G]. Antitumoral activity of lenalidomide in in vitro and in vivo models of mantle cell lymphoma involves the destabilization of cyclin D1/p27KIP1 complexes. Clin Cancer Res 2014; 20: 393-403. PMID: 24178620
Sola B, Poirot M, de Medina P, Bustany S, Marsaud V, Silvente-Poirot S, Renoir JM. Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism. Oncotarget 2013; 4: 911-922. PMID: 23978789
Cahu J, Bustany S, Sola B. Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells. Cell Death Dis 2012; 3: e446. PMID: 23254289

Last update : November 12, 2018

Université de Caen Normandie
équipe MICAH
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